Rupita 10mg Tablet 10pcs

Uses of Rupatadine

Allergic-rhinitis and urticaria.

How does Rupatadine work?

Rupatadine works by blocking the effects of histamine (chemical messenger) which causes allergic reactions, thereby providing relief from allergic symptoms such as swelling, itching, running nose, sneezing, rashes, and watery eyes. 

Side Effects of Rupatadine

• Sleepiness
• Headache
• Dizziness
• Dry mouth
• The sensation of weakness and fatigue

Quick Suggestions:

• Take rupatadine exactly as prescribed by your doctor. Follow the recommended dosage, frequency, and duration of treatment. Do not adjust the dose without consulting your doctor
• Drinking water regularly can help alleviate any dry mouth you may experience as a side effect of rupatadine
• Rupatadine is not recommended for use in pregnant women. Consult your doctor before taking rupatadine
• Rupatadine should be used during breast-feeding only if considered necessary or treatment with this medicine should be discontinued considering the benefit of breastfeeding for the child. Consult your doctor before taking
• Avoid consumption of alcohol and grapefruit while taking Rupatadine as it can increase the risk of side effects like drowsiness

Indication of Rupatadine

Rupatadine is used to relieve the symptoms of allergic rhinitis such as sneezing, runny nose, and itching in the eyes and nose which is also used to relieve the symptoms associated with urticaria (an allergic skin rash) such as itching and hives (localized skin redness and swelling).

Pharmacology

Rupatadine acts as a long-acting antagonist of histamine H1-receptors and platelet-activating factor (PAF). These substances contribute to bronchoconstriction and increased vascular permeability in inflammatory processes. By targeting both histamine and PAF, Rupatadine provides enhanced therapeutic effects compared to single-action antihistamines. It also inhibits mast cell degranulation triggered by various stimuli and suppresses the release of cytokines, including tumor necrosis factor-alpha (TNF α), in human mastocytes and monocytes.

Dosage & Administration of Rupatadine

• Adults and adolescents (over 12 years): The standard dose is 10 mg once daily, with or without food.
• Children aged 2 to 11 years:
  • For children weighing 25 kg or more: 1 teaspoonful (5 ml) of the oral solution once daily, with or without food.
  • For children weighing equal to or more than 10 kg to less than 25 kg: 1/2 teaspoonful (2.5 ml) oral solution once daily, with or without food.

Elderly:

Use cautiously; no dose adjustment is currently indicated.

Children:

Safety and efficacy have not been established in patients under 12 years of age.

Patients with renal or hepatic insufficiency:

Not recommended due to lack of relevant clinical data.

Overdose Effects:

The most common adverse reaction in cases of overdose is drowsiness. In the event of accidental ingestion of very high doses, provide symptomatic treatment and supportive measures.

Interaction

• Medication interactions: Concurrent use of Rupita 20 mg with ketoconazole or erythromycin can increase systemic exposure. Caution is advised when co-administered with these substances and other CYP3A4 inhibitors, statins, CNS depressants, or alcohol.
• Food interactions: Grapefruit and grapefruit juice should not be consumed simultaneously with Rupatadine.

Contraindications

Avoid Rupatadine in individuals with hypersensitivity to Rupatadine or any excipients.

Pregnancy & Lactation:

Clinical data on Rupatadine's effects during pregnancy are lacking. Pregnant women should avoid using Rupatadine unless the potential benefits outweigh the risks. Its excretion in breast milk is uncertain, so it's generally not recommended during lactation unless the benefits outweigh the risks.

Precautions & Warnings:

Exercise caution in patients with known QT interval prolongation, uncorrected hypokalemia, or ongoing proarrhythmic conditions. Use with care in elderly patients (65 years and older). Currently, there's limited clinical experience in patients with impaired kidney or liver function, so the use of Rupita 10 mg tablets is not recommended in these cases.

Storage Conditions:

Store below 30°C in a cool, dry place, away from light and moisture. Keep out of reach of children.